With respect to the in-silico modeling and simulation, a major challenge lies in the well-posed and numerically efficient coupling of the processes at the cell level with the macroscopic behavior and the mechanical properties of the tissue. The active processes at the cell level, such as cell differentiation and matrix synthesis, have a strong impact on the resulting tissue structure and quality, while macroscopic effects in turn are important stimuli for the processes at the microscopic level. Moreover, the time scales of the different processes differ vastly and call for appropriate co simulation strategies.
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